Self-replication is the preeminent property of living systems and natural materials. Nature builds and repairs by self-replication. Purely synthetic materials so far lack this important ability. An indispensable prerequisite is the multi-directional control of interactions between the building blocks of materials. In order to generate colloidal building blocks, which are able to self-replicate in a non-biological two-step process, i.e. without the use of DNA, we propose to create a new class of patchy colloidal particles bearing three patches of two different chemical functionalities. The new production process will yield precise control over the patch location and chemistry and thus also gives particles that go well beyond known ABA- or ABC-type Janus particles. For synthesis and replication of colloidal superstructures (e.g. particle strands), the colloids will carry two patches that allow irreversible crosslinking of the self-assembled master-strand and one patch that serves for the recognition and reversible attachment of the single particles along the colloidal chain for the replication process. Thus, in analogy to the polymerase chain reaction (PCR) for DNA replication, single tri-valent colloids will reversibly attach to the colloidal master strand, followed by inter-particle crosslinking of the newly formed strand, which then is detached form the master by opening the bonds between the strands. The released chain copy will then serve as template for further replication processes in which the number of copies will double after each cycle. With this approach we aim to establish a technology platform for the production of sufficient quantities of simple and complex colloidal assemblies, where a well-defined or complex master-structure can only be produced and isolated in small amounts due to a difficult and tedious synthetic procedure.
Integrating ecologic, economic and socio-economic effects, ecoDESIGN will strongly contribute to sustainability and future competitiveness of the European aviation industry according the European Eco innovation agenda. It covers the assessment of materials, processes and resources (MPR) employed along the entire aircraft life cycle. Based on the fundamental structure of eight Eco themes , ecoDESIGN enables an extended Life Cycle Analysis (LCA+), going far beyond aircraft operation. As a Transversal Activity in Clean Sky 2 ecoDESIGN concentrates on the development and integration of fundamental methodologies, tools and databases into a comprehensive platform and on the assessment and evaluation of innovative technology developments within the SPDs. Extending the coverage of the technology base for ecoDESIGN, validated LCI Data will be employed to derive Eco-Statements and to enable future standardized, consistent and comparable analysis with regard to Design for Environment (DfE) Approaches as of 2020. In parallel, ecoDESIGN will monitor the socio economic development of the European aviation industry in Clean Sky 2 by means of socio-economic derivative.
Rapid and sensitive analyte determination in small volumes is one of the main tasks in modern diagnostics for the development of miniaturized in vitro test systems. This is critically important for both health and environmental diagnostics. The traditional approach (ELISA) is a time-consuming multistep process with sensitivity limitations due to usually used planar supports for detection. In this project we intend to develop a new approach for biosensing based on porous antibody microparticles. For this purpose, the combination of a new technique to assemble porous particles at mild conditions (host know-how) and highly sensitive ELISA-based detection system (applicant know-how) will be used. The porous particles will work as a platform with two crucial features: i) specific immunochemical reactions are realized on highly developed particle surface, ii) separation and detection in small volumes (micrometer dimensions). We believe that the proposed approach may open new avenues in future for effective diagnostics.
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