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2,978 Research products, page 1 of 298

  • Energy Research
  • National Institutes of Health

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  • Publication . Article . Other literature type . 2007
    Open Access English
    Authors: 
    Mikhail A. Karymov; Alexey V. Krasnoslobodtsev; Yuri L. Lyubchenko;
    Publisher: Biophysical Society
    Project: NSF | Single Molecule Studies o... (0615590), NIH | LOCAL AND GLOBAL STRUCTUR... (5R01GM062235-03)

    AbstractA single-molecule analysis was applied to study the dynamics of synaptic and presynaptic DNA-protein complexes (binding of two DNA and one DNA duplex, respectively). In the approach used in this study, the protein was tethered to a surface, allowing a freely dif...

  • Open Access
    Authors: 
    John J. Lemasters; Ekhson Holmuhamedov;
    Publisher: The University of North Carolina at Chapel Hill University Libraries
    Project: NIH | LIVER PRESERVATION FOR TR... (5R01DK037034-08), NIH | Administrative Core and E... (5P30DK034987-28), NIH | INDUCTION OF AP1 AND NFKB... (5P50AA011605-04)

    AbstractDespite a detailed understanding of their metabolism, mitochondria often behave anomalously. In particular, global suppression of mitochondrial metabolism and metabolite exchange occurs in apoptosis, ischemia and anoxia, cytopathic hypoxia of sepsis and multiple...

  • Open Access
    Authors: 
    A. Morozenko; I. V. Leontyev; Alexei A. Stuchebrukhov;
    Publisher: American Chemical Society (ACS)
    Project: NIH | Theoretical Studies of Bi... (5R01GM054052-09), NSF | Computaional study of DNA... (0646273)

    The energetics of water molecules in proteins is studied using the water placement software Dowser. We compared the water position predictions for 14 high-resolution crystal structures of oligopeptide-binding protein (OppA) containing a large number of resolved internal...

  • Open Access English
    Authors: 
    Robert Clark; Venkatesh Krishnan; Michael Schoof; Irving Rodriguez; Betty Theriault; Marina Chekmareva; Carrie W. Rinker-Schaeffer;
    Publisher: American Society for Investigative Pathology. Published by Elsevier Inc.
    Project: NIH | PROSTATE CANCER METASTATI... (5R01CA089569-04)

    The goal of controlling ovarian cancer metastasis formation has elicited considerable interest in identifying the tissue microenvironments involved in cancer cell colonization of the omentum. Omental adipose is a site of prodigious metastasis in both ovarian cancer mode...

  • Open Access English
    Authors: 
    Purbasha Sarkar; Elena Bosneaga; Edgar G. Yap; Jyotirmoy Das; Wen-Ting K Tsai; Angelo Cabal; Erica Neuhaus; Dolonchampa Maji; Shailabh Kumar; Michael Joo; +6 more
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Software Maintenance for ... (5R01EB004873-03), NIH | STRUCTURAL INTERMEDIATES ... (2P01GM051487-05)

    Cost-effective production of lignocellulosic biofuel requires efficient breakdown of cell walls present in plant biomass to retrieve the wall polysaccharides for fermentation. In-depth knowledge of plant cell wall composition is therefore essential for improving the fue...

  • Open Access
    Authors: 
    Gabriel Rosenblum; Chunlai Chen; Jaskiran Kaur; Xiaonan Cui; Haibo Zhang; Haruichi Asahara; Shaorong Chong; Zeev Smilansky; Barry S. Cooperman; Yale E. Goldman;
    Publisher: Elsevier BV
    Project: NIH | Single Molecule Dynamics ... (5R01GM080376-04), NIH | FUNCTION AND ASSEMBLY OF ... (1R01GM052302-01)

    The rate of translation of full-length proteins by the ribosome influences expression levels, folding and frameshifting. In order to study the factors that control translation rates, we use the expression of fast maturing Emerald Green Fluorescent Protein (EmGFP) by a r...

  • Open Access
    Authors: 
    Daniel R. Larson; Yu May Ma; Volker M. Vogt; Watt W. Webb;
    Publisher: Rockefeller University Press
    Project: NSF | Nanoscope for Individual ... (0080792), NIH | BIOTECHNOLOGY RESOURCE--D... (3P41RR004224-08S1), NSF | STC: The Nanobiotechnolog... (9876771)

    During retrovirus assembly, the polyprotein Gag directs protein multimerization, membrane binding, and RNA packaging. It is unknown whether assembly initiates through Gag–Gag interactions in the cytosol or at the plasma membrane. We used two fluorescence techniques—two-...

  • Open Access
    Authors: 
    Xiaofei Nan; Gang Fu; Zhengdong Zhao; Sheng Liu; Ronak Y. Patel; Haining Liu; Pankaj R. Daga; Robert J. Doerksen; Xin Dang; Yixin Chen; +1 more
    Publisher: Springer Science and Business Media LLC
    Project: NSF | Modeling and Simulation o... (0903787), NIH | IN VITRO PHARMACOLOGY COR... (5P20RR021929-05), NIH | RENOVATION OF FOURTH FLOO... (1C06RR014503-01)

    Abstract Background It is commonly believed that including domain knowledge in a prediction model is desirable. However, representing and incorporating domain information in the learning process is, in general, a challenging problem. In this research, we consider domai...

  • Open Access
    Authors: 
    Christina E. M. Schindler; Martin Zacharias;
    Publisher: Elsevier BV
    Project: NIH | Dynamic Analysis of Rho G... (1R01HL097431-01A2), NIH | National Resource for Cel... (9P41GM103313-15), NIH | Heat Shock Proteins and t... (1R01GM098455-01A1), NIH | Bringing BioNetGen Rule-B... (5R01GM095485-02)

    Many of the most important processes in the cell are carried out by large molecular machines built up from multiple proteins. However, structural data for a large fraction of known and putative complexes is still lacking. Computational docking methods aim at predicting ...

  • Open Access
    Authors: 
    Matthew G. Rees; Mindy I. Davis; Min Shen; Steve Titus; Anne Raimondo; Amy Barrett; Anna L. Gloyn; Francis S. Collins; Anton Simeonov;
    Publisher: Public Library of Science (PLoS)
    Country: United Kingdom
    Project: NIH | Genetic analysis of type ... (1Z01HG000024-09), WT | Bridging the gap from typ... (095101)

    Recent genetic and clinical evidence has implicated glucokinase regulatory protein (GKRP) in the pathogenesis of type 2 diabetes and related traits. The primary role of GKRP is to bind and inhibit hepatic glucokinase (GCK), a critically important protein in human health...